IMPROVED IMMUNE PARAMETERS
I’M-YUNITY® possesses immune supporting benefits and potentially enhances our immune surveillance in some weak immune systems. Studies have shown that polysaccharopeptide boosts the activity of natural killer cells , stimulates the production of helper T cells (CD4+) to cytotoxic T cells (CD8+). In addition, it can induce the secretion of cytokine such as α and γ interferon.
ALLEVIATED SIDE EFFECTS OF CHEMO & RADIATION
In the 2005 edition of Pharmacopeia of the People’s Republic of China, Yun-zhi (Coriolus) was described as regulating the immune function. Also, clinical studies have demonstrated that polysaccharopeptide could stabilize white blood cell counts and alleviate chemotherapy and radiotherapy symptoms including nausea, fatigue and loss of appetite, when used as adjunct therapy.
STABLISED WHITE BLOOD CELL COUNTS
Another phase II, randomised, double –blinded, placebo-controlled clinical trial supported by our company group successfully published in Respiratory Medicine journal showed that polysaccharopeptide (PSP) had significant improvement on the white blood cells and neutrophil counts in patients with stage III and IV non-small cell lung cancer (P<0.05). Significant improvements were also seen in serum IgG and IgM in comparison with the control group. (p<0.05)
DRUG – HERB INTERACTION
A clinical study conducted in the U.S. suggested that the administration of I’m-Yunity® with other medications and dietary supplements which are primarily metabolised by CYP3A4, a subtype of the P450 enzyme pathway, is NOT expected to be associated with significant herb-drug interactions.
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- Liu Jx, et al. Phase II clinical trial for PSP capsules. PSP International Symposium (ed. Yang QY and Kwok CY), 183-208 (Fudan University Press, 1993)
- Yang JC, et. al Al. The stimulation and inductive effects of Coriolus versicolor polysaccharopeptide (PSP) on interferon. Advanced research in PSP (ed. Yang, Q.Y.), 164-167 (The Hong Kong Association for Health Care Ltd., 1999)
- Shiu WCT, et al. A clinical study of PSP on peripheral blood counts during chemotherapy. Phytotherapy research. 6, 217-218 (1992).
- Kidd PM. The use of mushroom glucans and proteoglycans in cancer treatment. Alternative Medicine Review. 5, 4-27 (2000).
- Tsang KW, et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Respiratory Medicine. 2003 Jun; 97(6):618-24.
- Nicandro JP, et al. In vivo effect of I’m-YunityTM on hepatic cytochrome P450 3A4. Journal of Herbal Pharmacotherapy. 7, 39-56 (2007).